The absence of a massive re-assortment of the nuclear envelope during mitosis is quite significant in terms of maintaining epigenetic marks and the mechanisms by which specific DNA sequences are incorporated into heterochromatin, as in metazoa several lamin-dependent mechanisms that deliver loci to heterochromatin occur as a component of mitosis and reassembly of the nuclear envelope at late anaphase, which clearly cannot be the case for trypanosomes. 40 Hence it is unclear just how many of the proteins that control entry, exit and maintenance of heterochromatin are shared across the eukaryotes.
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