Barely Significant
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Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.

PLoS One · 2012 · PMC3517545 · PMID 23236378

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a strong trendno p-value reported
These findings show a strong trend of reduced expression of aArrs and increased expression of bArrs in breast cancer.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.