Expression patterns of the immunomodulatory enzyme arginase 1 in blood, lymph nodes and tumor tissue of early-stage breast cancer patients.

13 The expression of ARG1 is increased in the peripheral blood mononuclear cells from breast cancer patients We observed a trend towards a higher frequency of ARG1-expressing cells in peripheral blood mononuclear cells (PBMCs) from cancer patients compared with those from HDs, though this did not reach statistical significance ( Fig. 1A ).

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The difference in ARG1 expression between cells obtained from breast cancer patients and HDs became highly significant when the comparison was limited to CD11b + cells ( Fig. 2A ).

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