Simulated evolution of signal transduction networks.

PLoS One · 2012 · PMC3521023 · PMID 23272078

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a clear trendno p-value reported

There is a clear trend that weaker interaction permit stronger transient activation of the monophosphorylated forms ( , , & in Fig. 8 ). 3.6 Evolution of SNs by adding new proteins We next evolve our randomly generated SNs by adding new proteins instead of altering kinetic parameters.

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