Plasma inflammatory markers (tumor necrosis factor-α [TNF-α], monocyte chemoattractant protein-1 [MCP-1], and IL12p70) tended to be higher in TDAG51 −/− mice, but did not reach statistical significance ( Supplementary Fig. 5 A ).
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Loss of TDAG51 results in mature-onset obesity, hepatic steatosis, and insulin resistance by regulating lipogenesis.
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