HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.

With the exception of integration nearby CpG islands, which likely attained a modest significance due to our large datasets ( P = 0.037), the Hdgfrp2 KO did not significantly impact the frequencies at which HIV-1 targets mouse genomic features ( Table 1 ; Figures 5 and 6 ).

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