Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice.

J Exp Med · 2012 · PMC3526355 · PMID 23230000

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showed a trendno p-value reported

3 A , the double neutralization of IFN-γ and TNF did not prevent pathology development but rather showed a trend toward accelerated disease progression.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.