ZFP36L1 negatively regulates plasmacytoid differentiation of BCL1 cells by targeting BLIMP1 mRNA.

pSicoR.zfp36l1.RNAi-transduced BCL1 cells proliferated less than wild-type, scramble or empty vector pSicoR virus control BCL1 cells in the absence of cytokines although this effect did not reach statistical significance ( Fig. 5A ).

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Thus, although the expression patterns of ZFP36L1 and BLIMP1 were not mutually exclusive, there appeared to be an overall trend of ZFP36L1 expression that was reciprocal to that of the plasma cell regulator, BLIMP1 and that decreased in cell lines of plasma cell phenotype.

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