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Reorienting the Fab domains of trastuzumab results in potent HER2 activators.

PLoS One · 2012 · PMC3527469 · PMID 23284778

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showed a trendno p-value reported
The agonistic bis-Fabs showed a trend toward being more compact molecules, as judged by their hydrodynamic radii ( Table 1 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.