Although elevated IL-17A transcription was also found in the present study in PPD-B stimulated PBMC from vaccinated/protected compared to vaccinated/un-protected calves, the differences did not quite reach statistical significance (data not shown).
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Global gene transcriptome analysis in vaccinated cattle revealed a dominant role of IL-22 for protection against bovine tuberculosis.
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Associations that did not reach statistical significance were also demonstrated with the Cytosolic DNA Sensing, Cancer and Acute Myeloid Leukemia pathways ( Figure 4 ).