The regulatory effect of miRNAs is a heritable genetic trait in humans.

Of these PicTar ( slope = 0.62 ± 0.36; p = 1.3 × 10 −3 ), miRanda [ 30 ]( slope = 0.40 ± 0.37; p = 3.6 × 10 −2 ) and mirTarget2 [ 31 ] ( slope = 0.35 ± 0.32; p = 2.8 × 10 −2 ) showed significant evidence of heritability, while one miRNA target prediction algorithm, mirBase [ 32 ], did not reach statistical significance ( slope = 0.20 ± 0.33; p = 0.21).

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