CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine.

As demonstrated in Figure 3 A and 3 B , there was a highly significant correlation between CD4 + T-cell expansion and both the maximum ( r = 0.53, P < .0001) and fold-increase in ( r = 0.46, P = .0004) microneutralization titer.

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We found a trend toward greater numbers of CD4 + T cells specific for this unique pool, but the increase did not reach statistical significance (Figure 2 C ).

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