Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway.

Although the presence of 2-AP marginally increased cytotoxicity in 3 of the cell lines, the effect did not reach statistical significance (SIHN-11B (Figure 8 A, P = 0.068), PJ41 (Figure 8 B, P = 0.14), HN3 (Figure 8 C, P = 0.07) or HN5 (Figure 8 D, P = 1.0)).

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