Embedding siRNA sequences targeting apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy.

Mol Ther · 2013 · PMC3538299 · PMID 23089734

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a clear trendno p-value reported

In addition, there was a clear trend of a slower loss of plasma ApoB and cholesterol inhibition in mice injected with AAV-miApoB as compared with AAV-shApoB indicating that miApoB had a better long-term efficacy than shApoB ( Figure 3c,d ).

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