These differences did not reach statistical significance because of the strong linkage disequilibrium (LD) between DRB1*08∶03 and DQB1*06∶01 which results in a low frequency of DRB1*08∶03 in patients without DQB1*06∶01 .
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Association of increased frequencies of HLA-DPB1*05:01 with the presence of anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese rheumatoid arthritis and systemic lupus erythematosus patients.
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