Although additional analyses did not show a significant interaction between body mass index, sex, or race, and C‐peptide levels, we did find an interaction of borderline significance ( P =0.04) between kidney function and the highest quartile of C‐peptide levels.
Of note, analyses of specific outcomes such as death due to ischemic heart disease and myocardial infarction did not reach statistical significance, except for cerebrovascular disease death (adjusted HR=3.94, 95% confidence interval [CI] 1.28 to 12.1), although their 95% CIs of these specific outcomes overlap with those of cardiovascular and overall mortality ( Table 5 ).