Metabolic side-effects of the novel second-generation antipsychotic drugs asenapine and iloperidone: a comparison with olanzapine.

This was highly significant for the 5 and 15 mg/kg doses (p<0.001), which increased glucose levels by 24% and 69% compared to controls.

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Similarly, asenapine significantly affected insulin resistance [F (5,43) = 2.59, p<0.05], measured by HOMA-IR, as insulin resistance was significantly reduced with the lowest asenapine dose (0.01 mg/kg) and a strong trend with the next two doses (0.05 and 0.1 mg/kg) ( Table 1 ).

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