Barely Significant
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Leptin locally synthesized in carotid atherosclerotic plaques could be associated with lesion instability and cerebral emboli.

J Am Heart Assoc · 2012 · PMC3541612 · PMID 23316287

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However, the difference between the groups with regard to those features did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.