Prolonged, low-dose anti-thymocyte globulin, combined with CTLA4-Ig, promotes engraftment in a stringent transplant model.

While the number of IFNγ-producing cells increased slightly in the untreated versus treated mice in response to OVA re-stimulation, this did not reach statistical significance (immunized during treatment = 368±49 vs immunized untreated = 462±16 spots, n = 3, p = 0.06), indicating that, despite pld-mATG+CTLA4-Ig treatment, the mice remained capable of a nominal antigen recall response.

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