Endotoxin tolerance variation over 24 h during porcine endotoxemia: association with changes in circulation and organ dysfunction.

In the primary analysis, the ex vivo TNF-α values showed different temporal dynamics than the in vivo values as indicated by a highly significant group by time interaction analysis comparing the ex vivo and the in vivo values after the TNF-α peak, i.e. from 3 to 24 h (p = 0.002).

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Although not reaching statistical significance at all time points, there was an obvious trend towards a negative correlation between early excretion of nitrate/nitrite and ΔTNF-α during the following hours, thus indicating an association between higher NO and increased endotoxin tolerance also in the present study.

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The group by time interaction did not reach statistical significance.

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