Impact of apoptotic adipose-derived mesenchymal stem cells on attenuating organ damage and reducing mortality in rat sepsis syndrome induced by cecal puncture and ligation.

Rat mortality rate 72 hours after CLP Unexpectedly, the mortality rate was notably higher in CLP animals treated with H-ADMSCs [mortality 62.5% (10/16)] than CLP animals without treatment [mortality 37.5% (6/16)] but this difference did not reach statistical significance (p = 0.289) (Figure 1A ).

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Moreover, we have recently demonstrated that treatment with ADMSCs profoundly reduced rodent acute lung ischemia-reperfusion injury through highly significant suppression of oxidative stress and inflammation [ 21 ].

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