Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo.

Biochem Pharmacol · 2013 · PMC3545186 · PMID 23063411

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did not reach statistical significanceno p-value reported

5 A), however this difference did not reach statistical significance.

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a small trendno p-value reported

A small trend of increased accumulation, compared to the absence of inhibitor (1.2-fold in MDCKII-ABCC1 and 1.4-fold in MDCKII-ABCC2) was seen when co-incubating Act D with MK571, but was not statistically significant ( Fig. 3 C).

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