Glucocorticoid repression of inflammatory gene expression shows differential responsiveness by transactivation- and transrepression-dependent mechanisms.

PLoS One · 2013 · PMC3545719 · PMID 23349769

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hedged sentences

0.0001

closest p · 0.0× alpha

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boldest claim

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highly significantP <0.0001actually significant

Furthermore, a highly significant ( P <0.0001) correlation between maximal efficacy and log potency of dexamethasone-mediated repression amongst genes was observed, thus confirming this observation ( Figure 2D , Table S3 ).

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failed to reach significanceno p-value reported

Equally, IRF1, which is partially repressed by dexamethasone, showed reversal by ORG34517 , but this failed to reach significance.

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did not reach statistical significanceno p-value reported

In respect of PRIC285, a marked loss of dexamethasone-dependent repression was observed in the presence of GR-specific siRNA, but this did not reach statistical significance.

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