Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis.

Furthermore, the amount of axonal loss and number of swollen axons within the demyelinated lesion appeared to be reduced in CD4-depleted mice compared with their undepleted B7-H1 −/− counterparts; however, the difference in axonal loss did not reach statistical significance by quantitative analysis (Figure 9B ).

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