Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials.

In the subgroup meta-analysis by the number of participants in each trial, vitamin or antioxidant supplements showed a trend toward a decreased (but not significant) risk of major cardiovascular events (relative risk 0.97, 95% confidence interval 0.94 to 1.01; I 2 =40%) in the subgroup meta-analysis of trials with <10 000 participants, while those supplements showed an increased (but not significant) risk of the major cardiovascular events (1.02, 0.99 to 1.04; I 2 =39%) in the subgroup meta-analysis of those with ≥10 000 participants (table 4).

also in 53,322 other papers

We found no significant beneficial effect of vitamin and antioxidant supplements in most of the subgroup meta-analyses, while only vitamin E supplements had a marginally significant decreased efficacy for the major cardiovascular events in high quality trials (relative risk 0.95, 95% confidence interval 0.90 to 1.00; I 2 =45%).

also in 26,082 other papers