Genetic association between APOE*4 and neuropsychiatric symptoms in patients with probable Alzheimer's disease is dependent on the psychosis phenotype.

In a recent genome-wide association study (GWAS), the odds ratio (OR) was 1.09 for the rs2927438 SNP in the APOE*4 locus that showed the strongest association between AD with and without psychosis, but this association did not reach statistical significance (p=.306) [ 5 ] However, the current study illustrates that these modest genetic effects might be obscured when the psychosis phenotype cannot be further subdivided (e.g., D+H or D alone).

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