Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity.

Indeed insertions in this exact location have been shown to activate Jdp2 expression, 34 and consistent with this, qPCR on RNA from tumours containing insertions in Jdp2 showed a trend towards having higher expression levels of Jdp2 and lower expression levels of Trp53 , relative to Trp53 +/− tumours with no insertions in Jdp2 (randomly selected from mice on this study that had not lost the Trp53 allele by mitotic recombination; Figure 3d ).

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