Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2.

The estimated cumulative HIV-1 incidence curves in the vaccine and placebo groups illustrate VE for two genotypes (K169 and I181X) and no efficacy for the opposite residues ( Supplementary Figure S2 ) (diagnostic tests did not show significant evidence of violation of the proportional hazards assumption) – and the cumulative HIV-1 incidence curves showed a trend toward waning vaccine effect on genotype over time, analogous to the temporal effect on efficacy seen in RV144 1 , 12 .

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These two sites showed significant or borderline significant results with the additional site-scanning methods (MMBootstrap and Model-based) ( Supplementary Table S3 ).

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