Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models.

Gut · 2013 · PMC3553490 · PMID 22543158

Europe PMC DOI

hedged sentences

0.1467

closest p · 2.9× alpha

0.6381

boldest claim

The sentences

did not reach statistical significancep=0.1467not close (p > 0.1)

The combination treatment showed reduced tumour growth compared with topotecan monotherapy, but this did not reach statistical significance (p=0.1467).

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failed to reach significancep=0.6381not close (p > 0.1)

By contrast, treatment with the continued FOLFOX-like therapy and control vehicle treatment followed by metronomic topotecan failed to reach significance compared with control animals (p=0.6381 and p=0.2812).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.