Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma.

Methylation of ccRCCs was not statistically associated with sex, age and lymph node metastasis status but showed a trend for the tumour diameter ( P =0.062). mir-124-3 methylation is associated with worse recurrence-free survival of patients To assess whether mir-124-3 methylation is associated with the clinical course of patients with ccRCC, we first performed a Cox regression analysis using a statistically calculated optimum cutoff value corresponding to a relative methylation level of 0.0015 for dichotomization of patients ( Figure 4B ).

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