Direct and indirect interactions of the dopamine D₃ receptor with glutamate pathways: implications for the treatment of schizophrenia.

Although the efficacy of BP 897 in acute or subacute schizophrenic patients was not demonstrated in this study, probably related to a low dose not reaching therapeutic levels, there was a strong trend toward an antipsychotic effect dependent on plasma exposure, supporting the hypothesis that a D 3 receptor antagonist or partial agonist could exhibit antipsychotic properties.

also in 5,725 other papers