High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling.

PLoS One · 2013 · PMC3561272 · PMID 23383172

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showed a trendno p-value reported

This result is consistent with previous research in which BL6/DBA mice were fed high zinc diets (300–1000 ppm) for 7–17 months, the brain zinc only showed a trend but no significant elevation [38] .

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