Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response.

A repeated-measures ANOVA showed a highly significant interaction between rs12082710 genotype (F 926,608 =4.8; P =9.28 × 10 –5 ) and time on change in HAM-D score.

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Comparing genes regulated by chronic paroxetine treatment in the mouse hippocampus with genes showing nominally significant association with antidepressant treatment response in two pharmacogenetic studies, the activin pathway was the only one to show this dual pattern of association and therefore selected as a candidate.

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