Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease.

It is worth noting, however, that using a slightly altered model–which treats APOE as a nominal or categorical ( carrier / non - carrier ) variable–in order to re-analyze a sub-set of this data which excludes these two ε2 subjects: 1) does not significantly alter the ε4 effects seen, and 2) still generates results suggestive of a protective morphometric main effect of a single ε2 allele (an effect size of +505.84 mm 3 , equivalent to a nearly 13% increase in hippocampal volume; Cohen’s d = 0.14, effect size r = 0.68)–though, this result is only marginally significant ( p = 0.07) (see Table 8 for a full summary of the results for this modified model).

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