Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest.

Region of interest (ROI) analysis confirmed a highly significant decrease in PE values in Met 158 -, compared to Val 158 , homozygotes (F 1,53 = 34.0; p < 0.000005; Fig. 2 , which was unaffected by the inclusion or exclusion of age as a covariate).

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We found no significant (or near-significant; p > 0.24) effects of COMT Val 158 Met on GM maps, consistent with some ( Zinkstok et al., 2006, 2008 ), but not all ( Ohnishi et al., 2006; Rowe et al., 2010 ), prior studies in healthy controls.

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