Human osteosarcoma tumor samples that had the lowest levels of miR-382 were at higher risk for metastasis (p-value 0.01) and showed a trend for death (p-value 0.08) than patients with moderate miR-382 expression independently confirming the observation that 14q32 miRNAs are a potential prognostic tool for osteosarcoma.
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MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma.
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The sentences
Specifically, our data showed highly significant downregulation of a large number of miRNAs at the 14q32 locus in human osteosarcoma compared to normal bone tissue, osteoblasts and other types of sarcomas [ 10 ].