Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance.

In contrast, the TRIP-Br2 KO mice fed a LFD showed a trend toward improved insulin sensitivity and a mild metabolic phenotype probably due to an insignificant reduction in their body weights ( Fig. 1g , Supplementary Fig. 8 , Supplementary Fig. 9a, 9b ).

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