Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.

We found that when CQ was administered therapeutically at a dose equivalent to that for human clinical use, the survival rate of H5N1 virus-infected mice was improved dramatically (from 0% to 70% at day 8 post infection), and the body weight changes also showed a trend of improvement, but prophylactic application of CQ showed no protective effect ( Figure 1B and 1C ).

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