Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults.

EMBO Mol Med · 2013 · PMC3569656 · PMID 23197416

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While on a CD for 20 weeks, Glis3 +/− and Glis3 +/+ mice displayed similar fasting blood glucose, glucose tolerance ( Fig 1C ) and plasma insulin during glucose tolerance test (GTT; Fig 1D ), although the Glis3 +/− showed a trend towards higher plasma glucose compared to Glis3 +/+ controls after glucose challenge ( Fig 1C ).

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