Cerebral biochemical pathways in experimental autoimmune encephalomyelitis and adjuvant arthritis: a comparative metabolomic study.

PLoS One · 2013 · PMC3573043 · PMID 23457507

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borderline significanceno p-value reported

In addition, the ketogenic and glucogenic essential amino acid, isoleucine (iso-leu), exhibited the same trend to similar Contr and CFA/SC-H levels (borderline significance, Table S3 A and D).

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a clear trendno p-value reported

Particularly increased BHB levels can be considered characteristic of EAE, although this brain metabolite is only moderately EAE-specific because BHB shows a clear trend toward increased levels also for animals with AA. 3.

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