Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies.

For patients treated during acute/early infection, a modest correlation that did not reach statistical significance was observed (r = 0.46, P = 0.18), but there was no correlation between the two assays for patients initiating HAART during chronic infection (r = −0.038, P = 0.87).

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Interestingly, there was a highly significant positive correlation between the level of integrated HIV-1 DNA in PBMC and the frequency of latently infected resting CD4 + T cells determined in the viral outgrowth assay on the same blood sample ( Figure 2D and Table 4 , r = 0.70, P = 0.0008).

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