highly significantP < 5 × 10 −7
QC exclusion criteria for SNPs were genotype call rates <0.90, highly significant deviation from Hardy–Weinberg equilibrium ( P < 5 × 10 −7 ) and minor allele frequency (MAF) < 0.005.
QC exclusion criteria for SNPs were genotype call rates <0.90, highly significant deviation from Hardy–Weinberg equilibrium ( P < 5 × 10 −7 ) and minor allele frequency (MAF) < 0.005.
Although the association between rs4916251 and AAA was only nominally significant ( P < 0.05) in one of the cohorts tested (the AC), it is important to note that the AC was the largest study with the greatest statistical power, and that the meta-analysis estimate showed little evidence of heterogeneity ( I 2 = 13%).