In the above-mentioned study on glucagon counterregulation during hypoglycemia, vildagliptin treatment enhanced the hypoglycemia-induced inhibition of insulin secretion and there was a clear trend by vildagliptin to increase the activity of the autonomic nervous system as indirectly observed by measuring the marker pancreatic polypeptide. 34 Therefore, several mechanisms may explain the protective effect of vildagliptin on glucagon counterregulation.
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Clinical evidence and mechanistic basis for vildagliptin's effect in combination with insulin.
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