Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2.

54 There was a tendency of reduced upregulation of Cox-2 mRNA in ERαAF-1 0 osteoblasts compared with WT osteoblasts subjected to strain in vitro at the 3-hour time point but it did not reach statistical significance.

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