QPCR in grafts and spleens from Cys treated mice at POD7 validated the preferential inhibition of Th1 responses by Cys seen in reduced graft IFN-y (p = 0.0101) and STAT4 (p = 0.0091) expression, whereas IL17A was not affected by Cys (p = 0.2180) but even showed a trend towards higher expression.
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Significance and suppression of redundant IL17 responses in acute allograft rejection by bioinformatics based drug repositioning of fenofibrate.
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