Silencing of Bmi1 expression in the Panc-1 cell line inhibited cell proliferation compared to lentiviral control shRNA infected cells, although our results did not reach statistical significance (177±12% vs. 141±16% at day 4, p = 0.11, n = 6 experiments, Figure 2B ).
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Bmi1 enhances tumorigenicity and cancer stem cell function in pancreatic adenocarcinoma.
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