Alpha-tomatine attenuation of in vivo growth of subcutaneous and orthotopic xenograft tumors of human prostate carcinoma PC-3 cells is accompanied by inactivation of nuclear factor-kappa B signaling.

In fact, both control and docetaxel treatment groups showed a trend of decreasing body weight after 14 days of cancer cells inoculation, potentially due to high tumor burden and toxicity of docetaxel, respectively ( Figure 4B ).

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