Exploring the interaction between SNP genotype and postmenopausal hormone therapy effects on stroke risk.

As a result, with a pre-determined threshold for marginal significance in the first-stage screening (chosen as 0.05), we only need to correct for the number of SNPs passing the first-stage filtering in evaluating gene-intervention interaction.

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The interactions of the two PCSK9 SNPs with either E-alone or E+P alone are only nominally significant.

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When the simultaneous interaction test with E-alone and E+P is further separated into its constituents, we observe highly significant evidence of interaction between the two F13A1 SNPs with E+P and nominally significant evidence of interactions between the two PCSK9 SNPs with E+P and E-alone for total stroke and for ischemic stroke specifically.

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