Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients.

In both omental and subcutaneous fat samples, there was a clear trend toward upregulation of mitochondrial function in individuals with low HOMA-IR, and the same trend was observed in individuals after treatment with TZDs.

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When broken-down to individual genes, the immune response gene set showed a highly significant inverse correlation between the two cohorts, consistent with the directionality of HOMA-IR response in these separate studies (parametric Pearson correlation; correlation degree, −0.60071; P = 6.4e-20) ( Fig. 2 B ).

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