Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab.

Int J Oncol · 2012 · PMC3583615 · PMID 22842582

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a clear trendno p-value reported

Even though these results were not statistically significant, there was a clear trend towards clinical benefit in this patient group.

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an interesting trendno p-value reported

There was an interesting trend to a longer time to progression in patients whose tumours had strong expression of total Akt2 or activated Akt (pAkt) detectable in both the cytoplasm and nucleus.

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an unexpected trendno p-value reported

We observed an unexpected trend towards improved TTP in patients with tumours with strong Akt2 expression (13.1 vs. 7.2 months) but the difference was not statistically significant (P=0.133; HR 0.682; 95% CI 0.42–1.12).

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